Scanning electron microscopic study of hyperacute rejection in the inbred rat
Leithner, C.; Piza-Katzer, H.; Kruzik, P.; Winter, M.; Mayr, W.R.; Stachelberger, H.; Sinzinger, H.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 15: 330-334
1978
ISSN/ISBN: 0071-2736 PMID: 368780 Document Number: 135137
Twenty skin-presensitised Lewis rats received kidney transplants from (Lewis X BN)f1 rats. Two grafts each were withdrawn at intervals from 1--120 min and examined using a scanning electron microscopic (SEM). A series of Lewis to Lewis isografts served as control. In hyperacute rejection at just 1 min spider-like fibrin fibres and platelets could be observed in small arteries, where the endothelium was severely altered. In these regions at 2 and particularly 5 min a fibrin network often contained platelet aggregates, mechanically altered erythrocytes as well as different kinds of leucocytes. This coagulation process progressed with time and resulted in a complete vascular occlusion at 30--60 min.