Experimental neuropathology and clinical neurology of chloroquine side effects
Klinghardt, G.W.
International Journal of Neurology 11(4): 331-341
1978
ISSN/ISBN: 0020-7446 PMID: 397203 Document Number: 133680
Experimental neuropathology has contributed a great deal to the understanding of neurological side effects of chloroquine therapy. The unusual clinical type of the myopathy in man is manifested by a predominant lesion of the type I muscle fibers. These changes are not neurogenic though the myopathy is combined with considerable axonal manifestations of ganglion cell changes in peripheral nerves. The type of nerve cell lesion caused by chloroquine was most successfully investigated in rat and rabbit posterior root ganglion cells and has provided an excellent model of neuronal storage dystrophy. Several CNS side effects of chloroquine are probably due to the selective participation of central nervous ganglion cell systems and ganglion cell types in the storage process, a finding established in studies with pigs.