Leukopenia and inflammation; the presence of a leukopenic factor in inflammatory exudates
Menkin, V.
Archives of Pathology 41: 50-62
1946
ISSN/ISBN: 0361-7017 PMID: 21014065 Document Number: 13355
A leukopenic factor is present in inflammatory exudates of dogs, particularly if the exudate gives an acid reaction. When injected into the blood stream of a normal animal, the leukopenic factor causes a rapid fall in the number of circulating leukocytes. In its present state of purification it is found as a rule to be closely associated with pyrexin, the substance primarily concerned in the development of the fever associated with inflammation. It can be dissociated from the pyrogenic factor by subjecting pyrexin to incomplete hydrolysis, which inactivates the pyrogenic factor. The evidence on hand does not as yet prove conclusively that the leukopenic factor is a substance separate from pyrexin. It may be only a separate factor in pyrexin. Further studies are in progress to establish this point. Preliminary observations indicate the probable polypeptide nature of the leukopenic factor
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