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The tumor-producing effect of automobile exhaust condensate and fractions thereof. Part I: chemical studies

Grimmer, G.; Böhnke, H.

Journal of Environmental Pathology and Toxicology 1(5): 661-667

1978

ISSN/ISBN: 0146-4779
PMID: 82600
Document Number: 133021
The criteria of a biological detection system discriminating carcinogenic and non-carcinogenic fractions of a mixture are discussed. Automobile exhaust gas condensate (in total 545.5 g) produced by a passenger car during the Europa driving cycle was separated into fractions with and without polycyclic aromatic hydrocarbons (PAH) by liquid-liquid distribution between methanol + water + cyclohexane and cyclohexane + nitromethane, respectively. PAH are highly potent carcinogens. To test non-PAH contribution to the total carcinogenic effect, these were separated from the PAH-containing fraction. Carbazol and acridine derivatives as well as aromatic amines remain predominantly in the PAH-free methanolic phase.

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