The effect of bleomycin on rat bone marrow cells
Bishun, N.P.; Valera, N.; Williams, D.C.
Cytobios 23(91-92): 177-185
1978
ISSN/ISBN: 0011-4529 PMID: 90585 Document Number: 132681
Experiments were carried out to determine the cytogenetic effects of the antibiotic bleomycin (BLM) in rats using the bone marrow system. A total of eighteen male and eighteen female Sprague-Dawley rats were injected with varying concentration of BLM, over varying periods of time. The results revealed that at low concentrations BLM showed no alteration in the ploidy or the morphology of rat chromosomes. This however, was not the case when the dose or administration period was increased.
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