Angiofollicular hyperplasia of lymph nodes (Castleman's hyperplasia)
Mildeová, E.; Lichtenberg, J.
Ceskoslovenska Patologie 14(3): 160-165
1978
ISSN/ISBN: 1210-7875 PMID: 709666 Document Number: 131915
Intrathoracic angiofollicular enlarged nodes illustrating two histological types according to Flendrig and Keller were removed in a 36- and an 18-year old man. Clinical symptomatology was absent in one of the patients, and disappeared in the other after resection. The histological pictures featured in particular: protein penetration from the hyperplastic vascular bed, regressive changes in the follicles, and plasmocytic hyperplasia. Vascular as well as interfollicular fibrosis were seen as one of the causes of visualization of normal follicular vascularization, which is normally poorly visible. The whole process, however, revealed increased interfollicular vascularization, the significance of which is the subject of discussion.