Neuroleptic infusion therapy with high-dosed fluphenazine
Fünfgeld, E.W.; Kulhanek, F.
Arzneimittel-Forschung 28(9): 1489-1491
1978
ISSN/ISBN: 0004-4172 PMID: 383096 Document Number: 131748
19 chronic schizophrenics who had previously been resistant to various neuroleptic treatment regimens, were given extemely high doses (ca. 300-500 mg daily) of fluphenazine. 2 infusions were given in the morning and in the afternoon. Therapy results, possible side effects and the transition to oral and i.m. (depot) modes of application are discussed. The above-mentioned extemely high doses of fluphenazine appear to be contra-indicated in depressive states and in cases of latent organic brain changes. Psychiatric state hospitals would be able to carry out this form of treatment in a special unit for "intensive care" in connection with appropriate social rehabilitative methods.