Hypothalamo-pituitary-thyroid axis function during cardiopulmonary bypass

Bremner, W.F.; Taylor, K.M.; Baird, S.; Thomson, J.E.; Thomson, J.A.; Ratcliffe, J.G.; Lawrie, T.D.; Bain, W.H.; Bremner, W.F; Taylor, K.M; Baird, S; Thomson, J.E; Thomson, J.A; Ratcliffe, J.G; Lawrie, T.D; Bain, W.H

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Hypothalamo-pituitary-thyroid axis function during cardiopulmonary bypass

Bremner, W.F.; Taylor, K.M.; Baird, S.; Thomson, J.E.; Thomson, J.A.; Ratcliffe, J.G.; Lawrie, T.D.; Bain, W.H.

Journal of Thoracic and Cardiovascular Surgery 75(3): 392-399

1978

ISSN/ISBN: 0022-5223

PMID: 416303

Document Number: 131597

Marked alterations in levels of circulating thyroid hormone were found in patients undergoing cardiopulmonary bypass with a rise in the free thyroxine and a fall in the free triiodothyronine levels. Studies using thyrotropin-releasing hormone during bypass demonstrated a blunted response to this stimulus. This reduced response is related to changes in thyroid hormone levels and it is suggested that bypass surgery may have a direct inhibitory action on thyroid-stimulating hormone release at the hypothalamo-pituitary level. The potential significance of these hormonal changes is discussed.