Gardner's syndrome in familial popyposis: clinical contribution and etiopathogenetic, therapeutic and prognostic considerations
Viola, S.; Caruso, E.; Carullo, F.; Burrafato, F.; Grasso, G.
Chirurgia Italiana 30(3): 209-226
1978
ISSN/ISBN: 0009-4773 PMID: 688542 Document Number: 131479
Starting from one case of Gardner's syndrome of their own observation, and in light of Watne's results, the authors argue that in the syndrome just named--and in familial polyposis in a broader sense--genetic factors do not play a predominant role; rather, polyps seem to result from the prolonged action of noxious agents. At any rate, said action can be neutralized, and possibly prevented either with a surgical modification of the distal gut or by treatment with a chemical substance identified as ascorbic acid. In view of these considerations, the authors recommend preventive medical therapy.