Demonstration of nonspecific suppressor cells in the peripheral lymphocytes of cancer patients
Quan, P.C.; Burtin, P.
Cancer Research 38(2): 288-296
1978
ISSN/ISBN: 0008-5472 PMID: 620401 Document Number: 130710
The response to phytohemagglutinin of peripheral blood lymphocytes was studied in 169 cancer patients. There was a significant decrease compared with control groups (normal persons and those with benign disease). By selecting cancer leukocyte samples with reactivity to phytohemagglutinin that was increased by carrageenan, a macrophage-toxic agent, and by mixing them with normal lymphocytes, we have demonstrated that the depressed phytohemagglutinin of six cancer patients' lymphoyctes was due to the presence of suppressor cells that possibly were monocytes.
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