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Polymorphism of the C-band segments of chromosomes 1, 9 and 16 in the peripheral blood lymphocytes of patients with endometrial cancer

Polishchuk, L.Z.; Nesina, I.P.

Tsitologiia i Genetika 27(4): 66-71

1993

ISSN/ISBN: 0564-3783
PMID: 8249167
Document Number: 405537
The paper presents results of investigation of constitutive heterochromatin of chromosomes 1, 9 and 16 in 23 patients with endometrial cancer and 5 women of the control group. The analysis was carried out on slides obtained by the routine method of the peripheral blood cell culture. The C-band segment variability was studied by the C-binding method. The investigation established an increase of polymorphism of constitutive heterochromatin in cancer patients, extreme variants and heteromorphism of homologues of chromosomes 1, 9 and 16. It is shown that polymorphism of the C-band on chromosomes 1, 9 and 16 in patients with cancer in their families increases as compared to the patients without cancer pathology in pedigrees.

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