Stimuli for intestinal phase of gastric secretion in dogs
Konturek, S.J.; Radecki, T.; Kwiecień, N.
American Journal of Physiology 234(1): E64-E69
1978
ISSN/ISBN: 0002-9513 PMID: 623252 Document Number: 130478
In 4 dogs with a special gastroduodenal fistula that allowed complete separation of the stomach and the duodenum, test meals (albumin, liver extract, amino acid mixture, individual amino acids, carbohydrate, fat and saline) were instilled into the duodenum; the gastric acid and serum gastrin responses were compared. The liver extract meal was the most effective stimulant of both gastric acid and serum gastrin, whereas albumin and the amino acid mixture made up to simulate the amino acid composition of albumin or liver extract were less potent. Amino acid mixture by vein also stimulated gastric acid secretion but not that of serum gastrin. Individual amino acids, instilled intraduodenally in 50 mmol/litre solutions, varied in secretory activity; the most active were serine, proline, glycine, leucine and valine, whereas tyrosine, cysteine, aspartic acid, histidine and tryptophan did not increase gastric acid secretion more than the saline control. L-Isomers of the most active amino acids produced greater acid outputs than D-isomers. The carbohydrate and fat meals in the intestine were ineffective in stimulation of gastric secretion.