Myocardial protection during ischemic cardiac arrest. the importance of magnesium in cardioplegic infusates
Hearse, D.J.; Stewart, D.A.; Braimbridge, M.V.
Journal of Thoracic and Cardiovascular Surgery 75(6): 877-885
1978
ISSN/ISBN: 0022-5223 PMID: 661356 Document Number: 130376
The increasing use of coronary infusates for the protection of the human heart drug ischemic cardiac arrest has placed great emphasis on the need for a rational and safe formulation of any infusion solution. Using a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest, we have found magnesium to be a highly effective component of protective infusates which can be additive to hypothermia and other protective agents. However, the concentration of magnesium bears a complex relationship to the degree of protection, a fact which stresses the need for the establishment of the correct concentration for optimal protection.