Reduced analgesic effects of morphine after bilateral lesions of the locus coeruleus in rats
Kostowski, W.; Jerlicz, M.; Bidziński, A.; Hauptmann, M.
Polish Journal of Pharmacology and Pharmacy 30(1): 49-53
1978
ISSN/ISBN: 0301-0244 PMID: 643740 Document Number: 130210
Noradnenaline-depleting lesions involving the locus coerulcus markedly reduced morphine analgesia. Rats were tested for analgesia using the tail-compression method. The results indicate that locus coeruleus plays an important role in analgesic action of morphine.
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