The interaction between alcohol, chlorpropamide and phenformin in a severe combined poisoning: case report
Manzo, L.; Allaria, B.; Richelmi, P.; Chiesa, G.; de Gasperi, A.; Crema, A.
Toxicological European Research. Recherche Europeenne en Toxicologie 1(4): 267-272
1978
ISSN/ISBN: 0249-6402 PMID: 369039 Document Number: 130115
A young non-diabetic woman ingested 2.5-3.7 g of chlorpropamide and 0.6-0.9 g of phenformin together with a large dose of alcohol, nitrofurantoin and promethazine in a suicidal attempt. She developed severe metabolic acidosis, hypokalemia, polyuria and prolonged hypoglycemia in the absence of typical hypoglycemic symptoms. These unusual clinical features were in part explained on the basis of the interactions between alcohol and the other drugs.