Expression of I-A and I-E,C region-coded Ia antigens on functional B cell subpopulations
Frelinger, J.A.; Hibbler, F.J.; Hill, S.W.
Journal of Immunology 121(6): 2376-2380
1978
ISSN/ISBN: 0022-1767 PMID: 82583 Document Number: 129333
Ia antigens from specific subregions have been examined on functional B cell populations. Expression of both I-A and I-E,C region antigens was demonstrated on cells required for both lipopolysaccharide mitogenesis and polyclonal activation. Similar I-A and I-E,C subregion expression was found on cells required for response to the T-independent antigen, polyvinylpyrrolidone. TNP-specific IgM and hen egg lysozyme-specific IgG plaque-forming cells also express I-A and I-E,C region antigens. No evidence was found for an Ia- population responsive in the systems tested. Further, no evidence of preferential expression of I-A or I-E,C region antigens was observed in any system examined. Therefore, it appears that B cells express both I-A and I-E,C region-coded Ia antigens.