Phase i study of neocarzinostatin in children with cancer
Rivera, G.; Howarth, C.; Aur, R.J.; Pratt, C.B.
Cancer Treatment Reports 62(12): 2105-2107
1978
ISSN/ISBN: 0361-5960 PMID: 156067 Document Number: 129157
Twenty-three children with advanced cancer refractory to conventional therapy received weekly iv doses of neocarzinostatin for 5 weeks. Doses were escalated from 500 to 6750 units/m2/week. Four types of toxic manifestations occurred: acute reactions consisting of shaking chills with or without fever and cyanosis (rigor), hypersensitivity, vomiting, and marrow depression. Evidence of oncolytic activity was limited to patients with acute leukemia in whom phase II trials at doses between 3000 and 4500 units/m2 appear warranted.
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