Inhibition of hepatic toxicities from polybrominated biphenyls and aflatoxin B in rats fed cauliflower
Stoewsand, G.S.; Babish, J.B.; Wimberly, H.C.
Journal of Environmental Pathology and Toxicology 2(2): 399-406
1978
ISSN/ISBN: 0146-4779 PMID: 216762 Document Number: 128812
Feeding diets containing cauliflower to rats inhibited hepatic residues of polybrominated biphenyls (PBB) with a reduction of fatty livers produced by 50 ppm of dietary PBB. Cauliflower diets also reduced the toxic effects of aflatoxin in Fischer rats, i.e., prevented mortality, internal hemorrhaging and reduced liver pathology. These diets enhanced hepatic aminopyrine N-demethylase and p-nitroanisole O-demethylase activities. A kinetic study of aryl hydrocarbon hydroxylase reaction rates showed that apparent Km was lower in liver, kidney and intestine, with a higher Vmax in the intestine. Microsomal enzyme induction, especially in liver and intestine, affords a detoxication mechanism of 2 widespread food contaminants when animals are under a cauliflower dietary regimen.