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Induction of preneoplastic hyperplasia and carcinoma by N-methyl-N'-nitro-N-nitrosoguanidine from regenerated mucosa of ulcers induced by iodoacetamide in fundus of rat stomach

Shirai, T.; Takahashi, M.; Fukushima, S.; Tatematsu, M.; Hirose, M.; Ito, N.

Gan 69(3): 361-366

1978

ISSN/ISBN: 0016-450X
PMID: 669137
Document Number: 128704
Differences in susceptibility to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) of fundic mucosa in various states of regeneration after induction of ulcer with iodoacetamide were examined histologically in male Wistar rats. Iodoacetamide was given to rats in their drinking water, before (Group 1), with (Group 2), or after (Group 3) MNNG. Atypical hyperplasia in the renewed mucosa and pyloric gland metaplasia were observed on the ulcers in Group 1 in higher incidence than in Groups 2 and 3. In addition, adenocarcinoma developed in the ulcer of 2 of 17 effective animals in Group 1. These observations suggest that the mucosa showing pyloric gland metaplasia is more susceptible to MNNG than the young rapidly regenerating mucosa at the margin of ulcers.

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