HIV-1 incidence estimates among young Thai men using IgG-capture BED-enzyme immunoassay (BED-CEIA) during 2005-2006
Kana, K.; Tabprasit, S.; Chuenchitra, T.; Sirisopana, N.; Rangsin, R.
Journal of the Medical Association of Thailand 92 Suppl. 1: S112-S116
2009
ISSN/ISBN: 0125-2208 PMID: 21299183 Document Number: 12819
Knowledge about the most recent HIV epidemic among young generation in Thailand is crucial for improving the prevention programs. It is important to distinguish between recent and long-term HIV-1 infections among the sero-surveillance populations to estimate the HIV-1 incidence. To obtain the HIV-1 incidence estimates in young Thai men from the HIV-1 sero-surveillance among the Royal Thai Army (RTA) conscripts inducted between November 2005 and November 2006. The confirmed HIV-1 positive serum samples obtained from the November 2005, May 2006, and November 2006 rounds of RTA conscripts induction were selected to be included in the study. The recent HIV-1 infections were detected among the confirmed HIV-1 positive serum samples using an HIV-1 BED incidence EIA Kit (Calypte HIV-1 BED Incidence EIA, Calypte Biomedical Corporation, Maryland, USA. The incidence estimates were obtained in each round of the induction using a consensus formula was agreed upon at the US Centers for Disease Controls and Preventions (CDC). Eighty seven thousand one hundred seventy eight RTA conscripts were tested for HIV-1 infection between November 2005 and November 2006. The prevalence of HIV-1 infection was 0.51%, 0.60%, and 0.50% for the period of November 2005, May 2006, and November 2006, respectively. The HIV-1 incidence estimates were 0.14%/year (95% CI, 0.09-0.20), 0.20% year (95% CI, 0.13-0.28), and 0.17%/year (95% CI, 0.10-0.29) in November 2005, May 2006, and November 2006, respectively. We reported the HIV-1 incidence estimates obtained from the IgG-capture BED-enzyme immunoassay (BED-CEIA) method in the RTA conscripts sero-surveillance population. The incidence estimates were ranging from 0.14% - 0.20%/year between November 2005 and November 2006. The estimates could serve as the recent baseline information for future HIV prevention interventions in Thailand.