Neuronal and liver protein synthesis in the developing offsprings following treatment of pregnant rats with ethanol or 1,3-butanediol
Khawaja, J.A.; Wallgren, H.; Usmi, H.; Hilska, P.
Research Communications in Chemical Pathology and Pharmacology 22(3): 573-580
1978
ISSN/ISBN: 0034-5164 PMID: 734235 Document Number: 126492
Ethanol or 1,3-butanediol ingestion during pregnancy and lactation results in a marked inhibition of neuronal protein synthesis in the 18-day-old rat progeny, however the same treatment had a stimulatory effect on the amino acid incorporation by neuronal perikarya of 8-day-old pups. Liver protein synthesis in vitro, on the other hand, was enhanced in both 8-day and 18-day-old pups as a consequence of maternal ethanol consumption. This was attributable to increased amino-acylation in the liver pH 5 enzyme fraction.