Inhibition of neutrophil Fc receptor function by cotricosteroids
Klempner, M.S.; Gallin, J.I.
Clinical and Experimental Immunology 34(1): 137-142
1978
ISSN/ISBN: 0009-9104 PMID: 750117 Document Number: 125343
The ability of hydrocortisone sodium succinate to inhibit the adherence of IgG-sensitized erythrocytes (EA) to human peripheral blood neutrophil monolayers is described. The steroid inhibitory effect was dose-dependent with a 32.4+/-2.4% decrease in EA binding at 2 X 10(-4)M. There was no difference between the addition of hydrocortisone prior to or at the same time as EA and steroid interference with EA binding was completely reversible. In addition, hydrocortisone was unable to displace bound EA. These findings suggest that hydrocortisone interferes with the availability of the neutrophil Fc receptor for binding and provides further insight into the host factors which are compromised during corticosteroid administration.