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Human alpha-fetoprotein and the estrogen receptor assay

Kiang, D.T.; Cavanaugh, A.; Lange, P.H.

Cancer Research 38(10): 3566-3567

1978

ISSN/ISBN: 0008-5472
PMID: 80266
Document Number: 124679
There are concerns that .alpha.-fetoprotein, a high-affinity estrogen binder in rat uterus, may mimic estrogen receptors in various human neoplasms, Using a sucrose gradient method and a dextran-coated charcoal method, human .alpha.-fetoprotein from germinal cell cancers did not have detectable estrogen-binding activity or interfere with estrogen receptor assay. Estrogen receptors detected in various human cancers by sucrose gradient and dextran-coated charcoal methods are not .alpha.-fetoprotein in origin.

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