Enhancement of melphalan therapy with glutaminase:asparaginase
Vistica, D.T.; Rabon, A.; Rabinovitz, M.
Research Communications in Chemical Pathology and Pharmacology 22(1): 83-92
1978
ISSN/ISBN: 0034-5164 PMID: 725323 Document Number: 124664
Depletion of glutamine with Acinetobacter glutaminase:asparaginase promotes melphalan uptake by and cytotoxicity to murine L1210 cells in vitro. Combined treatment of tumor bearing mice with these two agents increases the therapeutic response.
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