Quantitative changes of the formed elements of the blood during hepatic perfusion. 2. Effect of artificial oxygenation
Motta, G.; Bergomi, B.; De Luca, L.; Ratto, G.B.; Spinelli, E.; Merlini, E.; Nahum, M.
Bollettino della Societa Italiana di Biologia Sperimentale 53(11): 868-871
1977
ISSN/ISBN: 0037-8771 PMID: 563725 Document Number: 123779
The effects of 3 different types of oxygenators in an extracorporeal blood circulating system were compared for their denaturing action on blood and on trauma to formed elements. Fresh heparinized calf's blood was circulated for an average of 3 h and repeated 3 times for each extracorporeal system. Scores were kept on the reduction of the number of blood cells, hematocrit, white cells and platelets and of the degree of hemolysis. The membrane oxygenator produced the least trauma to blood cells, compared with the Polystan and Bentley bubble oxygenators. This better result was credited to the fact that, in the membrane oxygenator, contact between oxygen and blood was mediated by diffusion through a thin permeable membrane without the turbulence typical of the bubble oxygenators. Presence of oxygen improved trophic conditions and made blood cells more resistant to attrition. The relatively high denaturation in the equipment was attributed to the presence of 2 reservoirs with filters.