Action of atropine on histamine-induced bronchoconstriction in asthmatic children. a pharmacocapnographic study
Butor, E.; Murányi, L.
International Journal of Clinical Pharmacology and Biopharmacy 15(7): 321-324
1977
ISSN/ISBN: 0340-0026 PMID: 19362 Document Number: 123716
In their earlier methodological model studies the authors confirmed the protective effect of atropine in inhalative acetylcholine provocation. In the present work the role of parasympatholysis is investigated in histamine-induced bronchospasm by the method. It was found that a protective effect was exerted in histamine provocation repeated 20 minutes after subcutaneous administration of atropine sulphate in a dose of 0.01 mg/kg. The protective effect proved independent of the individual histamine sensitivities of the patients. The initial value of the CO2 curve prior to provocation was not improved.