Anticoagulant activity of triiodinated x-ray opaque media
Schulze, B.; Kaps, H.P.
Arzneimittel-Forschung 27(5): 972-975
1977
ISSN/ISBN: 0004-4172 PMID: 577882 Document Number: 123691
The anticoagulant activity of the triiodinated X-ray opaque media iodipamide, iothalamate and diatrizoate on standardized normal human pool plasma was investigated in vitro. We found a dose dependent lengthening of the thrombin time, the reptilase time and the partial thromboplastin time together with a dose dependent drop of the calcium thromboplastin and factor V activity. Iodipamide proved to exert the most pronounced anticoagulant activity of the 3 contrast media tested. The results are interpreted as latent disseminated intravascular coagulation with hyperfibrinolysis following the direct interaction of contrast media with the coagulation enzymes.