Oxidative metabolism of different structures of the central nervous system and its correlation with gastric ulcers by immobilization
Marin, B.; Menendez-Patterson, A.; Florez-Lozano, J.A.
Indian Journal of Medical Research 66(5): 852-858
1977
ISSN/ISBN: 0019-5340 PMID: 608756 Document Number: 123171
Oxidative metabolism of different structures of the CNS in physically immobilized male rats and the susceptibility to gastric ulcer formation were studied. Immobilization was carried out under 2 experimental conditions. Rats were exposed to stress with probable pain after developing intense peripheral edema and, in some cases, necrosis of the legs, which were tied up with string and wire. Another group were fastened with sticking-plaster and cotton pads to eliminate the probable pain factor and to get a purer experimental condition of stress by physical immobilizaiton. A control group of male rats was deprived of food for 48 h. In the experimental groups, both food deprivation and the immobilization caused stomach ulcerations. In relation to the experimental groups O2 uptake was higher in animals under painless immobilizaiton, the number of ulcers being significantly greater under painful physical immobilization. Adrenal weights showed significant differences in both experimental groups as compared to the control group, although a higher level of significance was found in the group with painless immobilization.