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The binding of 8-methoxypsoralen to nuclear DNA of UVA irradiated human fibroblasts in vitro

Bredberg, A.; Lambert, B.; Swanbeck, G.; Thyresson-Hök, M.

Acta Dermato-Venereologica 57(5): 389-391

1977

ISSN/ISBN: 0001-5555
PMID: 73303
Document Number: 122876
Human fibroblasts were exposed to 3H-labeled 8-methoxypsoralen (8-MOP) and longwave UV (UVA) light in vitro. The proportions of photochemically bound 8-MOP in the nucleus and cytoplasm were studied by autoradiography. The results show that UVA-irradiation of the cells in the presence of 8-MOP gives rise to a significant dose-dependent binding of 8-MOP in the cell nucleus.

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