Ankylosing spondylitis with selective IgA deficiency and a circulating anticoagulant
Good, A.E.; Cassidy, J.T.; Mutchnick, M.G.; Reed, R.E.; Lederman, H.M.
Journal of Rheumatology 4(3): 297-302
1977
ISSN/ISBN: 0315-162X PMID: 926106 Document Number: 122462
A patient with ankylosing spondylitis was found to have selective IgA deficiency and a non-heparin, immediate-acting antithrombin (antithrombin V). T cells were decreased, and serum IgG was increased. In vitro synthesis of IgG by peripheral blood lymphocytes was very high. This association of ankylosing spondylitis with the T cell and protein abnormalities is probably fortuitous but does demonstrate that severe spondylitis may evolve in the absence of IgA.