Complete sharing of light chain spectrotypes by murine IgM and IgG anti-streptococcal antibodies
Perlmutter, R.M.; Briles, D.E.; Davie, J.M.
Journal of Immunology 118(6): 2161-2166
1977
ISSN/ISBN: 0022-1767 PMID: 405425 Document Number: 122452
In order to examine the diversity of antibody light chains, we have developed an analytic isoelectric focusing procedure which permits the routine analysis of L chains from antibodies raised in individual mice. We have used this technique to demonstrate that the light chains of IgM and IgG anti-group A streptococcal antibodies raised in SWR mice are probably shared. Interestingly, numerous light chain spectrotypes are shared between individual mice whose 7S antibody focusing patterns differ.
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