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Changes in the quantity of nucleic acids in the liver and kidneys of rats with experimental lead poisoning

Zaprianov, Z.; Antov, G.

Farmakologiia i Toksikologiia 40(5): 617-619

1977

ISSN/ISBN: 0014-8318
PMID: 923785
Document Number: 122141
In the liver and kidneys of 125 control and test albino rats poisoned perorally daily with different doses of neutral lead acetate for 1, 3, 5, 10, 20, 30 and 45 days the RNA and DNA contest was measured. A statistically significant increase of nucleic acids was registered in both organs, earlier and stronger pronouced in the liver than in the kidneys. The amount of DNA changed quicker than that of DNA. In all the groups of animals the rise in the content was proportional to the introduced amount of lead (20, 40 and 100 mg/kg body weight). Following poisoning with 20 mg/kg of lead acetate the DNA and RNA accretion (statistically significant) remained after the 10th day roughly the same till the 45th day. The main reason for the DNA increment in the study organs seems to be an intensive synthesis, the rise of RNA is due to an inhibited activity of ribonuclease.

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