Top Abstract Purchase Related
Home
>
Node
>
Subnode

Human serum protein binding of cephalosporin antibiotics in vitro

Singhvi, S.M.; Heald, A.F.; Gadebusch, H.H.; Resnick, M.E.; Difazio, L.T.; Leitz, M.A.

Journal of Laboratory and Clinical Medicine 89(2): 414-420

1977

ISSN/ISBN: 0022-2143
PMID: 833477
Document Number: 121900
The published values for serum protein binding of antibiotics vary considerably depending upon the method and experimental conditions used. A rapid, simple, and standardized ultrafiltration procedure for determination of the serum protein binding of antibiotics has been developed and used to compare the binding characteristics of four marketed cephalosporins. The human serum protein binding of cephradine, cephalexin, cephalothin, and cefazolin at 37 degrees C. and physiological pH (7.4) was found to be 13.8, 12.4, 71.2, and 89.2 per cent, respectively. These values fall within the range of published values for these antibiotics.

Document emailed within 1 workday
Secure & encrypted payments

Nurakawa, T.; Nishida, M. 1970: Binding of penicillins with serum protein. 3. Relationship between protein-binding of penicillins and other antibiotics and gel affinity Japanese Journal of Antibiotics 23(3): 223-227
Yourassowsky, E.; Schoutens, E. 1975: In vitro bacteriostatic and bactericidal activities of 7 cephalosporin antibiotics on Haemophilus influenzae International Journal of Clinical Pharmacology and Biopharmacy 12(4): 433-436
Yu, H.Y.; Shen, Y.Z. 1982: Serum protein binding interaction between valproic acid and phenobarbital in vitro Journal of the Formosan Medical Association 81(12): 1482-1491
Ballou, S.P.; Buniel, J.; Macintyre, S.S. 1989: Specific binding of human C-reactive protein to human monocytes in vitro Journal of Immunology 142(8): 2708-2713
Brion, N.; Contrepois, A.; Carbon, C. 1983: From serum pharmacokinetics to extravascular pharmacokinetics of antibiotics. Importance of protein binding Presse Medicale 12(5): 293-296
Belpaire, F.M.; Vanderheeren, F.A.; Bogaert, M.G. 1975: Binding of thioridazine and some of its metabolites to human serum protein and human albumin Arzneimittel-Forschung 25(12): 1969-1971
Kindmark, C.O. 1972: In vitro binding of human C-reactive protein by some pathogenic bacteria and zymosan Clinical and Experimental Immunology 11(2): 283-289
Yacobi, A.; Levy, G. 1976: Effect of naproxen on protein binding of warfarin in human serum Research Communications in Chemical Pathology and Pharmacology 15(2): 369-372
Da Costa, M.; Rothenberg, S.P.; Fischer, C.; Rosenberg, Z. 1978: The identification and measurement of a folate-binding protein in human serum by radioimmunoassay Journal of Laboratory and Clinical Medicine 91(6): 901-907
Rochas, M.A.; Tufenkji, A.E.; Levillain, P.; Houin, G. 1991: Protein binding of methotrexate to human albumin and serum. a first derivative spectroscopic analysis Arzneimittel-Forschung 41(12): 1286-1288
Zhang, H.; Zhang, H.-f.; Chang, H.-c.; Han, X.; Bi, K.-s.; Chen, X.-h. 2011: Determination of protein binding rate of oleanolic acid in human plasma and serum albumin Yao Xue Xue Bao 46(2): 243-246
Chicault, M.; Luu Duc, C.; Boucherle, A. 1982: Drug -- protein interactions in vitro. Effect of levamisole on human serum albumin Arzneimittel-Forschung 32(4): 393-398
Waheed, A.; Winters, S.J.; Farrow, G.M.; Oshima, H.; Troen, P. 1985: Studies of the human testis. XIX. Preparation of an antibody to human testosterone-oestradiol-binding globulin and its application to the study of testicular androgen-binding protein Acta Endocrinologica 108(2): 284-288
Chojnowski, W.; Gralewicz, J. 1974: Some aspects of the binding of antibiotics to serum proteins Postepy Higieny i Medycyny Doswiadczalnej 28(4): 639-647
Bakhtiar, M.; Selwyn, S. 1987: Discrepancies in the effect of protein binding on beta-lactam antibiotics Chemioterapia: International Journal of the Mediterranean Society of ChemoTherapy 6(2 Suppl): 54-56
Yamamoto, N.; Homma, S.; Millman, I. 1991: Identification of the serum factor required for in vitro activation of macrophages. Role of vitamin D3-binding protein (group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages Journal of Immunology 147(1): 273-280
Imawari, M.; Akanuma, Y.; Itakura, H.; Muto, Y.; Kosaka, K.; Goodman, D.S. 1979: The effects of diseases of the liver on serum 25-hydroxyvitamin D and on the serum binding protein for vitamin D and its metabolites Journal of Laboratory and Clinical Medicine 93(1): 171-180
Stepanenko, O.'g.V.; Povarova, O.I.; Fonin, A.V.; Stepanenko, O.V. 2010: Stability of sugar-binding proteins: D-galactose/D-glucose-binding protein from Escherichia coli and trehalose/maltose-binding protein from Thermococcus litoralis Tsitologiia 52(11): 950-954
Creek, K.E.; St Hilaire, P.; Hodam, J.R. 1993: A comparison of the uptake, metabolism and biologic effects of retinol delivered to human keratinocytes either free or bound to serum retinol-binding protein Journal of Nutrition 123(2 Suppl): 356-361
Baeten, J.M.; Richardson, B.A.; Bankson, D.D.; Wener, M.H.; Kreiss, J.K.; Lavreys, L.; Mandaliya, K.; Bwayo, J.J.; McClelland, R.Scott. 2004: Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase response American Journal of Clinical Nutrition 79(2): 218-225