Treatment of amenorrhea-galactorrhea with bromo-ergocryptine. Apropos of 12 cases
Hartemann, P.; Leclere, J.; Groussin, M.; Valdenaire, J.C.; Maureira, J.J.; Belleville, F.; Nabet, P.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction 6(4): 537-546
1977
ISSN/ISBN: 0368-2315 PMID: 915214 Document Number: 121866
The authors report the action of bromergocryptine in 12 patients who were suffering from a syndrome of amenorrhoea with galactorrhoea and hyperprolactinism. None of these 12 patients had a pituitary tumour; or else they had been operated on before treatment. Only in one case was the syndrome linked to taking oral contraceptives, which had been stopped more than six months previously. The dose of bromergocryptine was 5 mg. a day. If this dose fails it is possible to raise it after two months' observation. The galactorrhoea disappeared or markedly decreased in 8 out of the 12 cases. Ovulatory cycles started in 9 out of the 12. 5 of the women wanted a pregnancy: 4 succeeded and 2 of them have already been delivered of normal children. Bromergocryptine (CB 154) has thus proved itself to be remarkably effective in hyperprolactinism, not caused by a pituitary tumour, which gives rise to amenorrhoea and galactorrhoea. All the same, its long-term use, especially after stopping treatment, is still to be evaluated.