On determining the levels of treatment to optimize the probability of a favorable response
Carter, W.H.; Wampler, G.L.; Crews, S.L.; Howells, R.
Cancer Treatment Reports 61(5): 849-853
1977
ISSN/ISBN: 0361-5960 PMID: 408002 Document Number: 121847
A statistical method is presented for analyzing the dose response surface associated with treatments resulting from combinations of any number of cytotoxic agents. The results of such an analysis are the dosages of each agent in the combination which will maximize the probability of a favorable response. An example utilizing a combination of hexamethylemelamine and ICRF-159 [1,2-bis(3,5-dioxopiperazin-1-yl)propane] is presented. The predictive ability of a model is verified by a X2 goodness of fit test. The advantages of such a method relate to its potential applicability to more complex experimental situations where multiple drugs are used in combination and/or where variations in timing of drug administration exist in mouse L1210 leukemia.