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Niridazole suppression of experimental allergic encephalomyelitis in Lewis rats

Paterson, P.Y.; Harvey, J.M.; Webster, L.T.

Journal of Immunology 118(6): 2151-2154

1977

ISSN/ISBN: 0022-1767
PMID: 301156
Document Number: 121439
Administration of niridazole to Lewis rats beginning 2 days before sensitization with guinea pig spinal cord in combination with immunologic adjuvants exerted a dose related suppressive influence on development of experimental allergic encephalomyelitis (EAE). A daily dose of 75 mg/kg completely prevented clinical neurologic signs as well as markedly suppressed occurrence of immunohistopathologic manifestations of this autoimmune disease. A higher daily dose level of niridazole, i.e., 100 mg/k, also inhibited EAE but was associated with neurotoxic manifestations.

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