Role of circulatory factors in the development of post-ischemic cerebral edema
Kapustinskiĭ, A.; Mchedlishvili, G.I.; Nikolaĭshvili, L.S.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1977(3): 23-29
1977
ISSN/ISBN: 0031-2991 PMID: 896285 Document Number: 121265
In experiments conducted on adult rabbits cerebral edema developed after the recovery of the cerebral circulation following cerebral ischemia (induced by bilateral occlusion of the common carotid arteries and restriction of the collateral circulation by controlled reduction of the systemic arterial pressure. The development of the postischemic cerebral edema is affected by an increase of the intravascular pressure caused by an increase of blood congestion. This is particularly pronounced when the blood outflow from the brain is limited as a result of elevated venous pressure. The compensation of the brain volume increase (caused either by a rise in the brain blood volume or by the cerebral edema) is realized by the fall of the pressure in the circle of Willis. This is apparently due to the rise in resistance in the internal carotid and vertebral arteries. The brain edema can be additionally compensated by an active reduction of the systemic arterial pressure.