Does resection of primary lesions show survival benefit for stage IV colorectal cancer patients with unresectable metastases?
Ichikawa, Y.; Goto, A.; Kobayashi, N.; Ota, M.; Tokuhisa, M.; Ishibez, A.; Watanabe, J.; Watanabe, K.; Ishikawa, T.; Tanaka, K.; Akiyama, H.; Fujii, S.; Endo, I.
Hepato-Gastroenterology 60(128): 1945-1949
2013
ISSN/ISBN: 0172-6390 PMID: 24719932 Document Number: 12106
The aims of the current retrospective cohort study were to compare OS of the primary resection (R-g) and the non-resection group (NR-g) after 2005. Ninety-five patients with stage IV colorectal cancer with unresectable distant metastases were divided into 2 groups; R-g; 37 and NR-g; 58. The only significant difference in clinical factors between the 2 was R0 resection rate (p = 0.007). The MST in R-g was superior to that in NR-g, 30.7 vs. 21.9 months (p = 0.031). After excluding the patients that underwent R0 resection, there was no difference in OS between the 2; however, the MST was 28.6 months in R-g and 17.1 months in NR-g. The advantage of resection of the primary is still unclear and a well-designed randomized Phase III study is expected. However, the current results suggest that resection of the primary lesion before intensive chemotherapy had some benefit for prognosis.
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