The influence of venous return on cardiac mechanical and sarcoplasmic reticulum function during endotoxemia
Hess, M.L.; Soulsby, M.E.; Davis, J.A.; Briggs, F.N.
Circulatory Shock 4(2): 143-152
1977
ISSN/ISBN: 0092-6213 PMID: 144571 Document Number: 120538
E. coli endotoxin (0.03 mg/ml) added to blood perfusing a heart-lung preparation with a venous return of 600 ml/min produced a significant depression in ventricular function within 4 hours. Fragmented sarcoplasmic reticulum isolated from the myocardium of the endotoxin-perfused heart-lung preparations showed depressed calcium uptake rates and ATPase activity. When venous return was increased to 1,200 ml/min, gram-negative endotoxin had no effect on ventricular function, isolated fragmented sarcoplasmic reticulum calcium uptake, or ATPase activity. These observations suggest that gram-negative endotoxin or a product thereof acts in synergism with low venous return in order to depress myocardial function.