Attempts to boost tuberculin skin reactions by serum or blood transfer in BCG-vaccinated guinea-pigs
Lehmann, E.H.
Scandinavian Journal of Respiratory Diseases 58(1): 27-32
1977
ISSN/ISBN: 0036-5572 PMID: 841292 Document Number: 119877
In persons with waning sensitivity to mycobacterial antigens, skin reactivity to tuberculin may be maintained or enhanced as a result of tuberculin testing. Similar phenomena were observed in guinea-pigs. As tuberculin testing may lead to antibody formation, the booster effect might be due to circulating antibody. A series of 9 pilot experiments, including blood and serum transfer from boosted to unboosted BCG-vaccinated guinea-pigs, gave no support to this hypothesis.