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Influence of methylcobalamin and cyanocobalamin on the neoplastic process in rats

Kal'nev, V.R.; Rachkus, I.A.; Kanopkaĭte, S.I.

Prikladnaia Biokhimiia i Mikrobiologiia 13(5): 677-681

1977

ISSN/ISBN: 0555-1099
PMID: 199903
Document Number: 119831
The effect of methylcobalamine (5.6-dimethylbenzimidazolyl-Co-methylcobamide, CH3-B12) and cyanocobalamine (5,6-dimethylbenzimidazolyly-Co-cyanocobamide, CN-B12) on the growth of Walker's carcinosarcoma and longevity of white noninbred rats with implanted Zajdela ascites hepatoma was studied. The two agents exerted a similar effect. They 1) reduced the survival of rats with implanted Zajdela ascites hepatoma and Walker's carcinosarcoma; 2) did not increase the cell concentration in ascites; and 3) increased the total volume of ascites.

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