Effect of schizophrenic patients' serum on the physiological state of lymphocytes under in vitro conditions
Babaian, N.G.; Bonartsev, P.D.; Prilipko, L.L.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 77(9): 1361-1364
1977
ISSN/ISBN: 0044-4588 PMID: 303419 Document Number: 119654
The report is concerned with the action of the serum of schizophrenic patients on the physiological state of lymphocytes in normal donors. It was established that during the early stages of incubation the action of the serum in schizophrenic patients evokes the activation of lymphocytes in normal donors, that is seen in changes of the ultrastructure and adhesive properties of these cells. On the late stages of cultivation the serum of patients destroys 13.4 +/- 5.9% of lymphocytes of normal donors. In remaining population 21% of lymphocytes lose their capability to react to PHA stimulation by an increase of DNA content.