Urinary metabolites of amitriptyline in the dog
Hucker, H.B.; Balletto, A.J.; Demetriades, J.; Arison, B.H.; Zacchei, A.G.
Drug Metabolism and Disposition the Biological Fate of Chemicals 5(2): 132-142
1977
ISSN/ISBN: 0090-9556 PMID: 15805 Document Number: 119545
Dogs excreted approximately 45% of an oral dose of 14C-amitriptyline (30 mg/kg) in the urine in 24 h. Two new urinary metabolites of the drug were identified as dihydrodiol derivatives of amitriptyline and nortriptyline, respectively. The major metabolite in dog urine was 10-hydroxyamitriptyline, excreted mainly in conjugated form. Other metabolites were characterized as 10-hydroxynortriptyline, amitriptyline N-oxide, and nortriptyline. Together, these metabolites accounted for approximately 47% of the urinary radioactivity. [Amitryptyline is a tricyclic antidepressant drug.].