Neutropenia induced by systemic infusion of chemotactic factors
O'Flaherty, J.T.; Showell, H.J.; Ward, P.A.
Journal of Immunology 118(5): 1586-1589
1977
ISSN/ISBN: 0022-1767 PMID: 858915 Document Number: 119294
Autologous plasma, when exposed to complement-activating agents that generate leukotactic activity, induces transient neutropenia after infusion into rabbits. Trypsinized human C5 as well as the chemotactic fragment isolated from zymosan-activated human serum also induces transient neutropenia in rabbits, as do chemotactically active synthetic tripeptides. In each instance the neutropenia-inducing activity parallels the chemotactic activity. Thus, neutropenia-inducing activity and chemotactic activity seem to be related physiologic responses of neutrophils. In vivo margination and/or agglutination of leukocytes may underlie this phenomenon of neutropenia.