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Immunoglobulin FAB-fragments: specific activity and reactogenicity. III. Comparative study of the antigenic properties of anti-encephalitic gamma-globulin and FAB-fragments isolated from it

Barban, P.S.; Liubimova, G.N.; Pantiukhina, A.N.; Misenzhnikov, A.V.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 37-41

1977

ISSN/ISBN: 0372-9311
PMID: 70912
Document Number: 119026
Parenteral administration of antiencephalytic gamma-globulin and of the Fab-fragments, extracted from it, to rabbits stimulated the formation of specific antibodies. The maximal blood serum specific antibody level in rabbits reimmunized with Fab-fragments was much lower than that following the reimmunization of rabbits with gamma-globulin. Antibodies specific to gamma-globulin and Fab-fragments were concentrated in the gamma-globulin fraction of the immune sera and could be referred to the immunoglobulins of G class.

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