Optical resolution of N-acetyl- (R) (S) -p-methoxyphenylglycine by differential crystallization
Felder, E.; Pitre, D.
Il Farmaco; Edizione Scientifica 32(2): 123-128
1977
ISSN/ISBN: 0430-0920 PMID: 870339 Document Number: 118798
The optical resolution of the ammonium salt of N-acetyl-(R)(S)-p-metoxyphenylglycine was performed by differential crystallization producing the two enantiomeric forms with excellent optical purity. Hydrolysis with hydrochloric acid/hydrobromic acid yields the two enantiomers of p-methoxyphenylglycine and p-hydroxyphenylglycine respectively.
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