Collagen modifications after deep cutaneous burns in rats
Mazmanian, G.; Di Maio, D.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 171(2): 319-322
1977
ISSN/ISBN: 0037-9026 PMID: 142548 Document Number: 118731
Acid extracted collegen is prepared from rat skin 48 hours after burning ; the material obtained is purified by salt precipitation and fractionnated by carboxymethylcellulose chromatography as described by Piez (3). Control samples are studied by a similar procedure. It can be concluded that after burning, rat skin collagen becomes insoluble ; the result seems to be consistent with intra and intermolecular crosslinks formation.