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Cross-clade immunogenicity and antigen-sparing with an AS03 (A) -adjuvanted prepandemic influenza vaccine in a Thai population

Thongcharoen, P.; Auewarakul, P.; Hutagalung, Y.; Ong, G.; Gillard, P.; Drame, M.; Bock, H.L.

Journal of the Medical Association of Thailand 94(8): 916-926

2011

ISSN/ISBN: 0125-2208
PMID: 21863672
Document Number: 11858
The present study (NCT00449670) in Asian subjects (18-60 years) evaluated the manufacturing consistency of four formulations of 3.75 mg AS03(A)-adjuvanted H5N1 influenza vaccine, in terms of post-immunization Hemagglutination Inhibition (HI) titers against the A/Vietnam/1194/2004 and A/Indonesia/05/2005 strains. The immunogenicity and safety of the vaccine in the Thai population are reported herein. Subjects were randomized (2:2:2:2.:1:1) between four vaccine groups and two control groups to receive two doses of either the AS03(A)-adjuvanted or non-adjuvanted H5N1 vaccine formulations, 21 days apart. Sera were assayed for HI antibody titers against the two strains. After the second dose of AS03(A)-adjuvanted vaccine, 94.2% subjects in the H5N1-AS03(A) groups seroconverted and 94.9% subjects were seroprotected against the A/Vietnam/1194/2004 strain. Cross-clade immune response against the A/Indonesia/05/2005 strain was observed. All vaccine formulations had an acceptable safety profile. This antigen-sparing AS03(A)-adjuvanted influenza vaccine could be a suitable candidate for combating and mitigating future influenza pandemics.

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Cross-clade immunogenicity and antigen-sparing with an AS03(A)-adjuvanted prepandemic influenza vaccine in a Thai population

Guo, W.; Xu, J.; Wu, J.; Zhao, S.; He, H.; Shi, W.; Yu, D.; Li, J.; Gao, H.; Chen, J. 2014: Safety and immunogenicity of seasonal inactivated influenza vaccine (split virion) and cross-reactive antibody responses to the H7N9 avian influenza virus Zhonghua Liu Xing Bing Xue Za Zhi 35(8): 949-952
Sandrini, M.C.; Pregliasco, F.; Mensi, C.; Giardini, G.; Lucchi, T.; Santambrogio, D.; Annoni, G.; Vergani, C. 1997: Immunogenicity and efficacy field evaluation (1994-1995 season) of influenza vaccine in a noninstitutionalized elderly population Annali di igiene: medicina preventiva e di comunita 9(5): 373-379
Denny, L.; Hendricks, B.; Gordon, C.; Thomas, F.; Hezareh, M.; Dobbelaere, K.; Durand, C.; Hervé, C.; Descamps, D. 2013: Safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine in HIV-positive women in South Africa: a partially-blind randomised placebo-controlled study Vaccine 31(48): 5745-5753
Zhu, F.-C.; Chen, W.; Hu, Y.-M.; Hong, Y.; Li, J.; Zhang, X.; Zhang, Y.-J.; Pan, Q.-J.; Zhao, F.-H.; Yu, J.-X.; Zhang, Y.-S.; Yang, X.; Zhang, C.-F.; Tang, H.; Zhang, H.; Lebacq, M.; David, M.-P.; Datta, S.K.; Struyf, F.; Bi, D.; Descamps, D. 2014: Efficacy, immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Chinese women aged 18-25 years: results from a randomized controlled trial International Journal of Cancer 135(11): 2612-2622
Wheeler, C.M.; Castellsagué, X.; Garland, S.M.; Szarewski, A.; Paavonen, J.; Naud, P.; Salmerón, J.; Chow, S.-N.; Apter, D.; Kitchener, H.; Teixeira, J.úl.C.; Skinner, S.R.; Jaisamrarn, U.; Limson, G.; Romanowski, B.; Aoki, F.Y.; Schwarz, T.F.; Poppe, W.A.J.; Bosch, F.X.; Harper, D.M.; Huh, W.; Hardt, K.; Zahaf, T.; Descamps, D.; Struyf, F.; Dubin, G.; Lehtinen, M.; Denham, I.; Garland, S.M.; Mindel, A.; O'Sullivan, M.; Skinner, S.R.; Waddell, R.; De Sutter, P.; Poppe, W.A.J.; Tjalma, W.; De Carvalho, N.S.; Naud, P.; Teixeira, J.C.; Aoki, F.Y.; Diaz-Mitoma, F.; Dionne, M.; Ferguson, L.; Miller, M.; Papp, K.; Ramjattan, B.; Romanowski, B.; Somani, R.; Apter, D.; Karppa, T.; Kudjoi, N.; Kyha-österlund, L.; Lehtinen, M.; Levanen, H.; Lönn 2012: Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial LANCET. Oncology 13(1): 100-110
Lim, B.K.; Ng, K.Y.; Omar, J.; Omar, S.Z.; Gunapalaiah, B.; Teoh, Y.L.; Bock, H.L.; Bi, D. 2014: Immunogenicity and Safety of the AS04-adjuvanted Human Papillomavirus-16/18 Cervical Cancer Vaccine in Malaysian Women Aged 18-35 years: a Randomized Controlled Trial Medical Journal of Malaysia 69(1): 2-8
Keating, S.M.; Bollinger, R.C.; Quinn, T.C.; Jackson, J.B.; Carruth, L.M. 2002: Cross-clade T lymphocyte-mediated immunity to HIV type 1: implications for vaccine design and immunodetection assays Aids Research and Human Retroviruses 18(14): 1067-1079
Berezin, V.E.; Zaĭdes, V.M.; Isaeva, E.S.; Zhdanov, V.M. 1985: Immunogenicity of a subunit influenza vaccine in experiments on animals Voprosy Virusologii 30(2): 166-174
Zuccotti, G.V.; Cucchi, C.; Sala, D.; Giovannini, M. 2002: Immunogenicity and safety of a virosomal influenza vaccine in HIV-infected children Acta Paediatrica 91(4): 486; Author Reply 487
Zuccotti, G.V.; Cucchi, C.; Sala, D.; Giovannini, M. 2002: Immunogenicity and safety of a virosomal influenza vaccine in HIV-infected children Acta Paediatrica 91(4): 486; Author Reply 487
Phongsamart, W.; Sirisanthana, V.; Wittawatmongkol, O.; Maleesatharn, A.; Sudjaritruk, T.; Chearskul, P.; Aurpibul, L.; Sirisanthana, T.; Chokephaibulkit, K. 2011: Immunogenicity and safety of monovalent influenza a (H1N1) 2009 in HIV-infected Thai children Vaccine 29(47): 8705-8711
Erofeeva, M.K.; Mel'nikov, S.I.; Semchenko, A.V.; Korovkin, S.A.; Nikonorov, I.I.; Maksakova, V.L.; Voĭtsekhovskaia, E.M.; Erman, E.S.; Gonchar, V.V.; Pozdeev, V.K.; Drinevskiĭ, V.P. 2010: Clinical trial of safety and immunogenicity of new influenza vaccine Grifor in children Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 55-59
Zhang, X.-g.; Li, K.-b.; Ma, J.; Wang, N.-f.; Zhang, X.-m.; Sang, Y.-h.; Dong, J.; Xu, H.; Zeng, Y. 2009: Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza a virus Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 23(2): 97-99
Huan, L-Fang.; Yao, L-Hong.; Chen, A-Jun.; Cheng, C-Sheng.; Jia, R-Qing.; Tian, Q.; Bo, H.; Guo, J-Qiang.; Wang, M.; Shu, Y-Long.; Zhang, Z-Qing. 2007: Construction and immunogenicity study of DNA vaccine expressing human H5N1 influenza virus hemagglutinin Bing du Xue Bao 23(5): 366-370
Nitayaphan, S.; Pitisuttithum, P.; Karnasuta, C.; Eamsila, C.; de Souza, M.; Morgan, P.; Polonis, V.; Benenson, M.; VanCott, T.; Ratto-Kim, S.; Kim, J.; Thapinta, D.; Garner, R.; Bussaratid, V.; Singharaj, P.; el-Habib, R.; Gurunathan, S.; Heyward, W.; Birx, D.; McNeil, J.; Brown, A.E. 2004: Safety and immunogenicity of an HIV subtype B and e prime-boost vaccine combination in HIV-negative Thai adults Journal of Infectious Diseases 190(4): 702-706
2000: Delayed supply of influenza vaccine and adjunct ACIP influenza vaccine recommendations for the 2000-01 influenza season. Advisory Committee on Immunization Practices Mmwr. Morbidity and Mortality Weekly Report 49(27): 619-622
Kantor, J.; Irvine, K.; Abrams, S.; Snoy, P.; Olsen, R.; Greiner, J.; Kaufman, H.; Eggensperger, D.; Schlom, J. 1992: Immunogenicity and safety of a recombinant vaccinia virus vaccine expressing the carcinoembryonic antigen gene in a nonhuman primate Cancer Research 52(24): 6917-6925
Abarca, K.; Valdivieso, F.; Potin, M.; Ibáñez, I.; Vial, P. 2002: Immunogenicity and reactogenicity of a reduced antigen content diphtheria, tetanus and acellular pertussis vaccine dTpa) in 10 to 11 years old children and in adults Revista Medica de Chile 130(5): 502-510
Fu, Q.-p.; He, H.; Li, L.; Chen, H.-p.; Zeng, Y.-x.; Liu, Q.-l.; Fang, G.; Dong, C.-m.; Guo, S.-h.; Li, H.-g.; Wang, H.-y.; He, C.-s.; Zhou, S.-z.; Li, L.; Gu, S.-n.; Zhang, Z.-f.; Dai, M. 2009: The immunogenicity and safety of 10 microg recombination yeast hepatitis B vaccine applied in expanded population Zhonghua Yu Fang Yi Xue Za Zhi 43(10): 903-906
Chan, S.H.; Tan, P.T.N.; Han, H.H.; Bock, H.L. 2006: Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine as a single-dose booster in Singaporean adults Singapore Medical Journal 47(4): 286-290