Correlation Between Rotation Thrombelastometry ROTEM® Analysis and Standard Haemostatic Parameters During Liver Transplantation
Stancheva, A.; Spassov, L.; Tzatchev, K.
Clinical Laboratory 57(5-6): 407-413
2011
ISSN/ISBN: 1433-6510 PMID: 21755833 Document Number: 11807
Background: The determination of the correlations between simultaneously performed rotation thrombelastometry ROTEM® analysis and standard haemostatic analysis during liver transplantations is indispensable for performing an adequate perioperative haemostatic monitoring. Methods: Perioperative haemostatic monitoring was performed to 30 patients undergoing orthotopic liver transplantation (13 male (42 %) and 17 female (58 %), age: (mean ± SD; 21±17 years). Standard coagulation parameters (PT, APTT, FIB) were assessed chronometrically on STA-Compact Analyzer (Diagnostica Stago – La Roche), rotation thrombealstometry analyses - on ROTEM® analyzer (Petapharm GmbH) and platelets (PLT) – on Cell Dyn 3700 (Abbott Diagnostica), MAPSS technology. Results: A protocol was successfully developed for the implementation of perioperative haemostatic control during orthotopic liver transplantations, performing parallel thrombelastometric and standard haemostatic analyses. Significant correlation was established between PT(INR) and EXTEM_CFT ( r = 0.834; p Conclusions: The correlations found in the present study suggest to perform the haemoststic liver transplantation monitoring through a parallel systematic analysis of both standard and rotation thrombelastometry parameters and confirm the ROTEM® method as preferable and highly informative.
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