Copeptin and High Sensitive Troponin for a Rapid Rule Out of Acute Myocardial Infarction?
Giavarina, D.; Carta, M.; Fortunato, A.; Wratten, M.L.; Hartmann, O.; Soffiati, G.
Clinical Laboratory 57(9-10): 725-730
2011
ISSN/ISBN: 1433-6510 PMID: 22029188 Document Number: 11782
Background: Rapid and reliable exclusion of acute myocardial infarction during emergency department triage is an important clinical need. The purpose of this study was to evaluate the potential role of copeptin, a marker of acute endogenous stress, together with high sensitive troponin-I for a rapid and early rule-out of acute myocardial infarction. Methods: Copeptin and myoglobin were measured in 80 subjects presenting to the emergency department with chest pain and symptoms suggestive of acute myocardial infarction, 46 patients had a negative high sensitive troponin-I concentration at presentation, 3, 6 and 12 hours; whereas 34 patients had negative or very low high sensitive troponin-I at presentation, but rising troponin values at 3, 6 and 12 hours. Results: Copeptin was significantly higher in patients with evidence of myocardial damage (median 92.2 pmol/L vs 8.5 pmol/L, p Conclusions: : Copeptin concentrations are more sensitive than myoglobin as an early marker of myocardial damage. Although copeptin provides significant incremental value on top of high sensitivity troponin-I, myoglobin does not.
Document emailed within 1 workday
